A-posteriori protein-rich dietary patterns and their association with ten-year transition to metabolically unhealthy status: highlights from a population-based cohort study

Abstract Background/Introduction The role of dietary protein on cardiometabolic health remains complex influenced by concomitant changes in overall diet composition. quality sources is currently suggested as more detrimental than the level consumption itself. Purpose association between different protein-rich patterns and 10-year transition to metabolically unhealthy status a sample from Greece was evaluated. Methods A prospective study conducted during 2001–2012 studying n=1,514 men n=1,528 women (>18 years old) free CVD. Healthy metabolic defined absence all NCEP ATP III (2005) syndrome components. Baseline assessment based validated semi-quantitative food frequency questionnaire. Dietary calculated through standardized database. Follow-up (2011–2012) achieved n=2,020 participants. Protein-rich were derived factor analysis subsample participants with high daily intake (>15% total energy corresponding median level). Patterns named according scores that correlated most (scores>0.5). Results Overall, six ten lost their healthy within decade. Multiadjusted revealed an inverse yet non-significant energy-standardized [Odds ratio (OR) (high vs. low intake)=0.59, 95% Confidence Interval (95% CI) (0.32, 1.10), p=0.09]. Factor extracted three patterns, explained 55% variation intake. characterized increased processed meet, unprocessed red meat eggs, B nuts seeds, legumes, whole grain products fish while C dairy products, poultry vegetables. logistic regression had strongest protective effect against [ORper 1 point increase score=0.74, CI (0.60, 0.85), p=0.01] followed marginally score=0.89, (0.73, 1.05), p=0.07]. Participants higher adherence likelihood lose score=1.15, (1.02, 1.30), p=0.04]. Conclusions present work confirms intake, outcomes observed consumed. FUNDunding Acknowledgement Type funding sources: None.